Environmental and Molecular Modulation of Motor Individuality in Larval Zebrafish.

ABSTRACT: Innate behavioral biases such as human handedness are a ubiquitous form of inter-individual variation that are not strictly hardwired into the genome and are influenced by diverse internal and external cues. Yet, genetic and environmental factors modulating behavioral variation remain poorly understood, especially in vertebrates. To identify genetic and environmental factors that influence behavioral variation, we take advantage of larval zebrafish light-search behavior. During light-search, individuals preferentially turn in leftward or rightward loops, in which directional bias is sustained and non-heritable. Our previous work has shown that bias is maintained by a habenula-rostral PT circuit and genes associated with Notch signaling. Here we use a medium-throughput recording strategy an

SUBMITTER: Hageter J 

PROVIDER: S-EPMC8685292 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature