Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression.

ABSTRACT: Major depressive disorder is a high-impact, debilitating disease and it is currently considered the most prevalent mental illness. It is associated with disability, as well as increased morbidity and mortality. Despite its significant repercussions in our society, its exact pathophysiology remains unclear and therefore, available antidepressant treatment options are limited and, in some cases, ineffective. In the past years, research has focused on the development of a multifactorial theory of depression. Simultaneously, evidence supporting the role of the endocannabinoid system in the neurobiology of neuropsychiatric diseases has emerged. Studies have shown that the endocannabinoid system strongly impacts neurotransmission, and the neuroendocrine and neuroimmune systems, which are known t

SUBMITTER: Gallego-Landin I 

PROVIDER: S-EPMC8685322 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature