Gut Microbiome, Inflammation, and Cerebrovascular Function: Link Between Obesity and Cognition.

ABSTRACT: Obesity affects 13% of the adult population worldwide and this number is only expected to increase. Obesity is known to have a negative impact on cardiovascular and metabolic health, but it also impacts brain structure and function; it is associated with both gray and white matter integrity loss, as well as decreased cognitive function, including the domains of executive function, memory, inhibition, and language. Especially midlife obesity is associated with both cognitive impairment and an increased risk of developing dementia at later age. However, underlying mechanisms are not yet fully revealed. Here, we review recent literature (published between 2010 and March 2021) and discuss the effects of obesity on brain structure and cognition, with a main focus on the contributions of the gut

SUBMITTER: Olsthoorn L 

PROVIDER: S-EPMC8685335 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature