B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation.

ABSTRACT: Germinal centers (GCs) are induced microanatomical structures wherein B cells undergo affinity maturation to improve the quality of the antibody response. Although GCs are crucial to appropriate humoral responses to infectious challenges and vaccines, many questions remain about the molecular signals driving B cell participation in GC responses. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an important mediator of type I interferon and proinflammatory cytokine responses during infection and cellular stress. Recent studies have reported important roles for STING in B cell responses, including an impact on GC B cells and downstream antibody responses, which could have great consequences for vaccine design and understanding STING-associated interferonop

SUBMITTER: Green K 

PROVIDER: S-EPMC8685402 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature