Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron Excitability.

ABSTRACT: Intrinsic membrane excitability (IME) sets up neuronal responsiveness to synaptic drive. Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K⁺ channels TASK1. However, intracellular partners linking GPCRs to TASK1 modulation are not yet well-known. We hypothesized that isoform 2 of rho-kinase (ROCK2), acting as downstream GPCRs, mediates adjustment of MN IME via TASK1. Electrophysiological recordings were performed in hypoglossal MNs (HMNs) obtained from adult and neonatal rats, neonatal knockout mice for TASK1 (task1 ^-/-) and TASK3 (task3 ^-/-, the another highly expressed TASK subunit in MNs), and primary cultures of embryonic spinal cord MN

SUBMITTER: Garcia-Morales V 

PROVIDER: S-EPMC8685439 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature