Phasing out DEHP from plastic indwelling medical devices used for intensive care: Does it reduce the long-term attention deficit of critically ill children?

ABSTRACT:

Background

Children who have been critically ill face long-term developmental impairments. Iatrogenic exposure to di(2-ethylhexyl)phthalate (DEHP), a plasticizer leaching from plastic indwelling medical devices used in the pediatric intensive care unit (PICU), has been associated with the pronounced attention deficit observed in children 4 years after critical illness. As concerns about DEHP toxicity increased, governmental authorities urged the phase out of DEHP in indwelling medical devices and replacement with alternative plasticizers. We hypothesized that exposure to DEHP decreased over the years, attenuating the pronounced long-term attention deficit of these vulnerable children.

Methods

We compared plasma concentrations of 3 oxidative DEHP metabolites (5cx-MEPP, 5OH-ME

SUBMITTER: Vanhorebeek I 

PROVIDER: S-EPMC8685605 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature