Evaluation of borinic acids as new, fast hydrogen peroxide-responsive triggers.

ABSTRACT: Hydrogen peroxide (H₂O₂) is responsible for numerous damages when overproduced, and its detection is crucial for a better understanding of H₂O₂-mediated signaling in physiological and pathological processes. For this purpose, various "off-on" small fluorescent probes relying on a boronate trigger have been prepared, and this design has also been involved in the development of H₂O₂-activated prodrugs or theranostic tools. However, this design suffers from slow kinetics, preventing activation by H₂O₂ with a short response time. Therefore, faster H₂O₂-reactive groups are awaited. To address this issue, we have successfully developed and characterized a prototypic borinic-based fluores

SUBMITTER: Gatin-Fraudet B 

PROVIDER: S-EPMC8685692 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature