Ontology highlight
ABSTRACT:
SUBMITTER: Lin CW
PROVIDER: S-EPMC8685897 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Lin Chih-Wei CW Wang Yu-Jen YJ Lai Ting-Yen TY Hsu Tsui-Ling TL Han Shin-Ying SY Wu Han-Chung HC Shen Chia-Ning CN Dang Van V Chen Ming-Wei MW Chen Lan-Bo LB Wong Chi-Huey CH
Proceedings of the National Academy of Sciences of the United States of America 20211201 50
Pancreatic cancer is usually asymptomatic in the early stages; the 5-y survival rate is around 9%; and there is a lack of effective treatment. Here we show that SSEA-4 is more expressed in all pancreatic cancer cell lines examined but not detectable in normal pancreatic cells; and high expression of SSEA-4 or the key enzymes <i>B3GALT5</i> + <i>ST3GAL2</i> associated with SSEA-4 biosynthesis significantly lowers the overall survival rate. To evaluate potential new treatments for pancreatic cance ...[more]