Sleep promotes the formation of dendritic filopodia and spines near learning-inactive existing spines.

ABSTRACT: Changes in synaptic connections are believed to underlie long-term memory storage. Previous studies have suggested that sleep is important for synapse formation after learning, but how sleep is involved in the process of synapse formation remains unclear. To address this question, we used transcranial two-photon microscopy to investigate the effect of postlearning sleep on the location of newly formed dendritic filopodia and spines of layer 5 pyramidal neurons in the primary motor cortex of adolescent mice. We found that newly formed filopodia and spines were partially clustered with existing spines along individual dendritic segments 24 h after motor training. Notably, posttraining sleep was critical for promoting the formation of dendritic filopodia and spines clustered with existing spi

SUBMITTER: Adler A 

PROVIDER: S-EPMC8685900 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature