Comparison of cerebral blood flow in subjects with and without chronic obstructive pulmonary disease from the population-based Rotterdam Study.

ABSTRACT:

Objectives

Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of cerebrovascular disease, which might be associated with decreases in cerebral blood flow. Since studies examining cerebral blood flow in COPD remain scarce and are limited by sample size, we aimed to study cerebral blood flow in participants with and without COPD.

Design

Observational cohort study.

Setting

Population-based Rotterdam Study.

Participants

4177 participants (age 68.0±8.5 years; 53% females) with and without COPD.

Predictor variable

Spirometry and pulmonary diffusing capacity.

Outcome measures

Cerebral blood flow by two-dimensional phase-contrast cerebral MRI.

Results

Compared with subjects with normal spirometry (forced expiratory vol

SUBMITTER: Wijnant SRA 

PROVIDER: S-EPMC8685943 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature