The impact of relative hypotension on acute kidney injury progression after cardiac surgery: a multicenter retrospective cohort study.

ABSTRACT:

Background

Cardiac surgery is performed worldwide, and acute kidney injury (AKI) following cardiac surgery is a risk factor for mortality. However, the optimal blood pressure target to prevent AKI after cardiac surgery remains unclear. We aimed to investigate whether relative hypotension and other hemodynamic parameters after cardiac surgery are associated with subsequent AKI progression.

Methods

We retrospectively enrolled adult patients admitted to 14 intensive care units after elective cardiac surgery between January and December 2018. We defined mean perfusion pressure (MPP) as the difference between mean arterial pressure (MAP) and central venous pressure (CVP). The main exposure variables were time-weighted-average MPP-deficit (i.e., the percentage difference between p

SUBMITTER: Kotani Y 

PROVIDER: S-EPMC8686086 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature