Viral metagenomics reveals two novel anelloviruses in feces of experimental rats.

ABSTRACT:

Background

Rodents are widely distributed and are the natural reservoirs of a diverse group of zoonotic viruses. Thus, analyzing the viral diversity harbored by rodents could assist efforts to predict and reduce the risk of future emergence of zoonotic viral diseases. Rodents are commonly used in animal testing, particularly mice and rats. Experimental rats are important animal models, and a history of pathogenic infections in these animals will directly affect the animal trial results. The pathogenicity of Anellovirus (AV) remains poorly understood due to the lack of a suitable model cell line or animal to support the viral cycle. This study aimed to discover possible anelloviruses from the virome in feces of experimental rats by viral metagenomic technique.

Methods

Fecal s

SUBMITTER: Ning SY 

PROVIDER: S-EPMC8686219 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature