Histopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model.

ABSTRACT:

Background

Multi-walled carbon nanotubes and nanofibers (CNT/F) have been previously investigated for their potential toxicities; however, comparative studies of the broad material class are lacking, especially those with a larger diameter. Additionally, computational modeling correlating physicochemical characteristics and toxicity outcomes have been infrequently employed, and it is unclear if all CNT/F confer similar toxicity, including histopathology changes such as pulmonary fibrosis. Male C57BL/6 mice were exposed to 40 µg of one of nine CNT/F (MW #1-7 and CNF #1-2) commonly found in exposure assessment studies of U.S. facilities with diameters ranging from 6 to 150 nm. Human fibroblasts (0-20 µg/ml) were used to assess the predictive value of in vitro to in vivo modeling syst

SUBMITTER: Fraser K 

PROVIDER: S-EPMC8686255 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature