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Dangers of hyperoxia.

ABSTRACT: Oxygen (O₂) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O₂, i.e. inspiratory O₂ concentrations (F_IO₂) > 0.21 may cause hyperoxaemia (i.e. arterial (a) PO₂ > 100 mmHg) and, subsequently, hyperoxia (increased tissue O₂ concentration), thereby enhancing ROS formation. Here, we review the pathophysiology of O₂ toxicity and the potential harms of supplemental O₂ in various ICU conditions. The current evidence base suggests that PaO₂ > 300 mmHg (40 kPa) should be avoided, but it remains uncertain whether there is an "optimal level" which may vary for given clinical conditions. Since even moderately supra-physiological PaO₂ may be associated with deleterious side effects, it seems advisable at present to titrate O₂ to maintain PaO₂ within the normal range, avoiding both hypoxaemia and excess hyperoxaemia.

SUBMITTER: Singer M

PROVIDER: S-EPMC8686263 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Dangers of hyperoxia.

Singer Mervyn M Young Paul J PJ Laffey John G JG Asfar Pierre P Taccone Fabio Silvio FS Skrifvars Markus B MB Meyhoff Christian S CS Radermacher Peter P

Critical care (London, England) 20211219 1

Oxygen (O2) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS). Supplemental O2, i.e. inspiratory O2 concentrations (FIO2) > 0.21 may cause hyperoxaemia (i.e. arterial (a) PO2 > 100 mmHg) and, subsequently, hyperoxia (increased tissue O2 concentration), thereby enhancing ROS formation. Here, we review the pathophysiology of O2 ...[more]

PMID: 34924022

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