DIPS (Dystonia Image-based Programming of Stimulation: a prospective, randomized, double-blind crossover trial).

ABSTRACT:

Introduction

Deep brain stimulation of the internal globus pallidus is an effective treatment for dystonia. However, there is a large variability in clinical outcome with up to 25% non-responders even in highly selected primary dystonia patients. In a large cohort of patients we recently demonstrated that the variable clinical outcomes of pallidal DBS for dystonia may result to a large degree by the exact location and stimulation volume within the pallidal region. Here we test a novel approach of programing based on these insights: we first defined probabilistic maps of anti-dystonic effects by aggregating individual electrode locations and volumes of tissue activated of > 80 patients collected in a multicentre effort. We subsequently modified the algorithms to be able to test all

SUBMITTER: Lange F 

PROVIDER: S-EPMC8686267 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature