A cascade targeting strategy based on modified bacterial vesicles for enhancing cancer immunotherapy.

ABSTRACT:

Background

As an efficient tumor immunotherapy, PD-1 antibody has been gradually used in clinical tumor treatment, but the low response rate and excessive immune response limit its extensive application.

Results

Herein, a therapeutic regime for the reinvigoration and activation of the tumor immune microenvironment is introduced to improve the anti-tumor effect of the PD-1 antibody. To comprehensively improve the effect of the immunotherapy and reduce excessive immune response, a biomimetic cascade targeting nanosystem, siRNA@PLOV, which was fused by photothermal sensitive liposomes (PTSLs) and attenuated Salmonella outer membrane vesicles (OMVs), was administered in the tumor therapy for targeting of tumor tissues and T cells within tumor respectively. The fused PLOVs which

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC8686283 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature