Intraosseous fluid resuscitation causes systemic fat emboli in a porcine hemorrhagic shock model.

ABSTRACT:

Background

Intraosseous cannulation can be life-saving when intravenous access cannot be readily achieved. However, it has been shown that the procedure may cause fat emboli to the lungs and brain. Fat embolization may cause serious respiratory failure and fat embolism syndrome. We investigated whether intraosseous fluid resuscitation in pigs in hemorrhagic shock caused pulmonary or systemic embolization to the heart, brain, or kidneys and if this was enhanced by open chest conditions.

Methods

We induced hemorrhagic shock in anesthetized pigs followed by fluid-resuscitation through bilaterally placed tibial (hind leg) intraosseous cannulas. The fluid-resuscitation was limited to intraosseous or i.v. fluid therapy, and did not involve cardiopulmonary resuscitation or other in

SUBMITTER: Kristiansen S 

PROVIDER: S-EPMC8686379 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature