HIV-1_LAI Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells.

ABSTRACT:

Background

A variety of hematopoietic abnormalities are commonly seen in human immunodeficiency virus-1 (HIV-1) infected individuals despite antiviral therapy, but the underlying mechanism remains elusive. Nef plays an important role in HIV-1 induced T cell loss and disease progression, but it is not known whether Nef participates in other hematopoietic abnormalities associated with infection.

Results

In the current study we investigated the influence of HIV-1_LAI Nef (LAI Nef) on the development of hematopoietic stem/progenitor cells (HSPCs) into myeloid-erythroid lineage cells, and found that nef expression in HSPCs blocked their differentiation both in vitro and in humanized mice reconstituted with nef-expressing HSPCs.

Conclusions

Our novel findings demo

SUBMITTER: Zou W 

PROVIDER: S-EPMC8686389 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature