Environmental and human health risk assessment of mixture of Covid-19 treating pharmaceutical drugs in environmental waters.

ABSTRACT: This study identified ecological and human health risks exposure of COVID-19 pharmaceuticals and their metabolites in environmental waters. Environmental concentrations in aquatic species were predicted using surface water concentrations of pharmaceutical compounds. Predicted No-Effect Concentrations (PNEC) in aquatic organisms (green algae, daphnia, and fish) was estimated using EC₅₀/LC₅₀ values of pharmaceutical compounds taken from USEPA ECOSAR database. PNEC for human health risks was calculated using the acceptable daily intake values of drugs. Ecological PNEC revealed comparatively high values in algae (Chronic toxicity PNEC values, high to low: ribavirin (2.65 × 10⁵ μg/L) to ritonavir (2.3 × 10^-1 μg/L)) than daphnia and fish. Risk quotient

SUBMITTER: Kumari M 

PROVIDER: S-EPMC8686450 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature