COSNet i : ComplexOme-Structural Network Interpreter used to study spatial enrichment in metazoan ribosomes.

ABSTRACT:

Background

Upon environmental stimuli, ribosomes are surmised to undergo compositional rearrangements due to abundance changes among proteins assembled into the complex, leading to modulated structural and functional characteristics. Here, we present the ComplexOme-Structural Network Interpreter (COSNeti), a computational method to allow testing whether ribosomal proteins (rProteins) that exhibit abundance changes under specific conditions are spatially confined to particular regions within the large ribosomal complex.

Results

COSNeti translates experimentally determined structures into graphs, with nodes representing proteins and edges the spatial proximity between them. In its first implementation, COSNeti considers rProteins and ignores rRNA and other objects. Spatial reg

SUBMITTER: Martinez-Seidel F 

PROVIDER: S-EPMC8686616 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature