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ABSTRACT: Background
Systemic sclerosis (SSc) is a rare detrimental disease warranting global research efforts. Evaluating how socio-economic factors impact country research output on SSc could help to identify solutions advancing research.Methods
Publication production on SSc during 1969-2018 and data for structural and policy factors for WHO member countries were collected from public sources. Associations between SSc research output and country-level factors were investigated through panel regression. Difference-in-differences analysis further assessed the causal effects of rare disease legislation.Results
SSc publications demonstrated exponential growth (r = 0.9410, as against an r = 0.8845 after linear adjustment), but were concentrated in high-income countries (HICs). T
SUBMITTER: Guo W
PROVIDER: S-EPMC8686627 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature