LDexpress: an online tool for integrating population-specific linkage disequilibrium patterns with tissue-specific expression data.

ABSTRACT: Genome-wide association studies have identified thousands of genetic susceptibility loci associated with cancer as well as other traits and diseases. Mapping germline variation in identified genetic susceptibility regions to alterations in nearby gene expression nominates candidate genes potentially related to disease risk for further functional investigation. We developed LDexpress as an online resource that integrates population-specific linkage disequilibrium data from the 1000 Genomes (1000G) project and tissue-specific expression data from the Genotype-Tissue Expression project to better study regional germline variation impacting gene expression. LDexpress is a publicly available web tool designed to be easy to use, flexible to conduct a wide range of variant queries, and quick to ef

SUBMITTER: Lin SH 

PROVIDER: S-EPMC8686638 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature