Clonally expanded, GPR15-expressing pathogenic effector T_H2 cells are associated with eosinophilic esophagitis.

ABSTRACT: Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the recruitment of eosinophils to the esophagus, resulting in chronic inflammation. We sought to understand the cellular populations present in tissue biopsies of patients with EoE and to determine how these populations are altered between active disease and remission. To this end, we analyzed cells obtained from esophageal biopsies, duodenal biopsies, and peripheral blood of patients with EoE diagnosed with active disease or remission with single-cell RNA and T cell receptor (TCR) sequencing. Pathogenic effector T_H2 (peT_H2) cells present in the esophageal biopsies of patients with active disease expressed distinct gene signatures associated with the synthesis of eicosanoids. The esophageal tissue

SUBMITTER: Morgan DM 

PROVIDER: S-EPMC8686696 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature