A Plasma Protein Biomarker Strategy for Detection of Small Intestinal Neuroendocrine Tumors.

ABSTRACT:

Background

Small intestinal neuroendocrine tumors (SI-NETs) are difficult to diagnose in the early stage of disease. Current blood biomarkers such as chromogranin A (CgA) and 5-hydroxyindolacetic acid have low sensitivity (SEN) and specificity (SPE). This is a first preplanned interim analysis (Nordic non-interventional, prospective, exploratory, EXPLAIN study [NCT02630654]). Its objective is to investigate if a plasma protein multi-biomarker strategy can improve diagnostic accuracy (ACC) in SI-NETs.

Methods

At the time of diagnosis, before any disease-specific treatment was initiated, blood was collected from patients with advanced SI-NETs and 92 putative cancer-related plasma proteins from 135 patients were analyzed and compared with the results of age- and sex-matched con

SUBMITTER: Kjellman M 

PROVIDER: S-EPMC8686712 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature