Sex differences in the immune response to acute COVID-19 respiratory tract infection.

ABSTRACT:

Background

Sex differences in COVID-19 are increasingly recognized globally. Although infection rates are similar between the sexes, men have more severe illness. The mechanism underlying these sex differences is unknown, but a differential immune response to COVID-19 has been implicated in several recent studies. However, how sex differences shape the immune response to COVID-19 remains understudied.

Methods

We collected demographics and blood samples from over 600 hospitalized patients diagnosed with COVID-19 from May 24th 2020 to April 28th, 2021. These patients were divided into two cohorts: Cohort 1 was further classified into three groups based on the severity of the disease (mild, moderate and severe); Cohort 2 patients were longitudinally followed at three time point

SUBMITTER: Qi S 

PROVIDER: S-EPMC8686792 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature