Construction and investigation of breast-cancer-specific ceRNA network based on the mRNA and miRNA expression data.

ABSTRACT: It has been proved and widely acknowledged that messenger RNAs can talk to each other by competing for a limited pool of miRNAs. The competing endogenous RNAs are called as ceRNAs. Although some researchers have recently used ceRNAs to do biological function annotations, few of them have investigated the ceRNA network on specific disease systematically. In this work, using both miRNA expression data and mRNA expression data of breast cancer patient as well as the miRNA target relations, the authors proposed a computational method to construct a breast-cancer-specific ceRNA network by checking whether the shared miRNA sponges between the gene pairs are significant. The ceRNA network is shown to be scale-free, thus the topological characters such as hub nodes and communities may provide impo

SUBMITTER: Zhou X 

PROVIDER: S-EPMC8687191 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature