Topological alternate centrality measure capturing drug targets in the network of MAPK pathways.

ABSTRACT: A new centrality of the nodes in the network is proposed called alternate centrality, which can isolate effective drug targets in the complex signalling network. Alternate centrality metric defined over the network substructure (four nodes - motifs). The nodes involving in alternative activation in the motifs gain in metric values. Targeting high alternative centrality nodes hypothesised to be destructive free to the network due to their alternative activation mechanism. Overlapping and crosstalk among the gene products in the conserved network of MAPK pathways selected for the study. In silico knock-out of high alternate centrality nodes causing rewiring in the network is investigated using MCF-7 breast cancer cell line-based data. Degree of top alternate centrality nodes lies between the

SUBMITTER: Md Aksam VK 

PROVIDER: S-EPMC8687289 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature