Interactive cooperation and hierarchical operation of microRNA and transcription factor crosstalk in human transcriptional regulatory network.

ABSTRACT: Transcriptional regulation of gene expression is an essential cellular process that is arranged by transcription factors (TFs), microRNAs (miRNA) and their target genes through a variety of mechanisms. Here, we set out to reconstruct a comprehensive transcriptional regulatory network of Homo sapiens consisting of experimentally verified regulatory information on miRNAs, TFs and their target genes. We have performed topological analyses to elucidate the transcriptional regulatory roles of miRNAs and TFs. When we thoroughly investigated the network motifs, different gene regulatory scenarios were observed; whereas, mutual TF-miRNA regulation (interactive cooperation) and hierarchical operation where miRNAs were the upstream regulators of TFs came into prominence. Otherwise, biological

SUBMITTER: Gov E 

PROVIDER: S-EPMC8687357 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature