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Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization.

ABSTRACT: The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in live virus and pseudovirus assays. Omicron was 41-84-fold less sensitive to neutralization than D614G and 5.3-7.4-fold less sensitive than Beta when assayed with serum samples obtained 4 weeks after 2 standard inoculations with 100 μg mRNA-1273. A 50 μg boost increased Omicron neutralization titers and may substantially reduce the risk of symptomatic vaccine breakthrough infections.

SUBMITTER: Doria-Rose NA 

PROVIDER: S-EPMC8687471 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization.

Doria-Rose Nicole A NA   Shen Xiaoying X   Schmidt Stephen D SD   O'Dell Sijy S   McDanal Charlene C   Feng Wenhong W   Tong Jin J   Eaton Amanda A   Maglinao Maha M   Tang Haili H   Manning Kelly E KE   Edara Venkata-Viswanadh VV   Lai Lilin L   Ellis Madison M   Moore Kathryn K   Floyd Katharine K   Foster Stephanie L SL   Atmar Robert L RL   Lyke Kirsten E KE   Zhou Tongqing T   Wang Lingshu L   Zhang Yi Y   Gaudinski Martin R MR   Black Walker P WP   Gordon Ingelise I   Guech Mercy M   Ledgerwood Julie E JE   Misasi John N JN   Widge Alicia A   Roberts Paul C PC   Beigel John J   Korber Bette B   Pajon Rolando R   Mascola John R JR   Suthar Mehul S MS   Montefiori David C DC  

medRxiv : the preprint server for health sciences 20211220

The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in live virus and pseudovirus assays. Omicron was 41-84-fold less sensitive to neutralization than D614G  ...[more]

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