Genetic risk factors associated with gestational diabetes in a multi-ethnic population.

ABSTRACT:

Aims

Genome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms in several genes. We investigated whether the same gene loci confer a risk for gestational diabetes mellitus (GDM) in women from Hawaii, and in particular, Pacific Islander and Filipino populations.

Methods

Blood was collected from 291 women with GDM and 734 matched non-diabetic controls (Pacific Islanders: 71 GDM, 197 non-diabetic controls; Filipinos: 162 GDM, 395 controls; Japanese: 58 GDM, 142 controls). Maternal DNA was used to genotype and show allele frequencies of 25 different SNPs mapped to 18 different loci.

Results

After adjusting for age, BMI, parity and gravidity by multivariable logistic regression, several SNPs

SUBMITTER: Benny P 

PROVIDER: S-EPMC8687569 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature