Tinnitus-like "hallucinations" elicited by sensory deprivation in an entropy maximization recurrent neural network.

ABSTRACT: Sensory deprivation has long been known to cause hallucinations or "phantom" sensations, the most common of which is tinnitus induced by hearing loss, affecting 10-20% of the population. An observable hearing loss, causing auditory sensory deprivation over a band of frequencies, is present in over 90% of people with tinnitus. Existing plasticity-based computational models for tinnitus are usually driven by homeostatic mechanisms, modeled to fit phenomenological findings. Here, we use an objective-driven learning algorithm to model an early auditory processing neuronal network, e.g., in the dorsal cochlear nucleus. The learning algorithm maximizes the network's output entropy by learning the feed-forward and recurrent interactions in the model. We show that the connectivity patterns and res

SUBMITTER: Dotan A 

PROVIDER: S-EPMC8687580 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature