Ontology highlight
ABSTRACT:
SUBMITTER: Siolas D
PROVIDER: S-EPMC8687588 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Siolas Despina D Vucic Emily E Kurz Emma E Hajdu Cristina C Bar-Sagi Dafna D
Cell reports 20210801 8
Tumor genotype can influence the immune microenvironment, which plays a critical role in cancer development and therapy resistance. However, the immune effects of gain-of-function Trp53 mutations have not been defined in pancreatic cancer. We compare the immune profiles generated by Kras<sup>G12D</sup>-mutated mouse pancreatic ductal epithelial cells (PDECs) engineered genetically to express the Trp53<sup>R172H</sup> mutation with their p53 wild-type control. Kras<sup>G12D/+</sup>;Trp53<sup>R172 ...[more]