Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling.

ABSTRACT:

Background

Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) as one of the most abundant proteases. ADAMTS5 cleaves chondroitin sulfate proteoglycans such as versican. The contribution of ADAMTS5 and its substrate versican to HF is unknown.

Methods

Versican remodeling was assessed in mice lacking the catalytic domain of ADAMTS5 (Adamts5^ΔCat). Proteomics was applied to study ECM remodeling in left ventricular samples from patients with HF, with a particular focus on the effects of common medications used for the treatment of HF.

Results

Versican and versikine, an ADAMTS-specif

SUBMITTER: Barallobre-Barreiro J 

PROVIDER: S-EPMC8687617 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature