Neural correlates of attentional control in social anxiety disorder: the impact of early-life adversity and DNA methylation.

ABSTRACT:

Background

Social anxiety disorder is characterized by intense fear and avoidance of social interactions and scrutiny by others. Although alterations in attentional control seem to play a central role in the psychopathology of social anxiety disorder, the neural underpinnings in prefrontal brain regions have not yet been fully clarified.

Methods

The present study used functional MRI in participants (age 18-50 yr) with social anxiety disorder (n = 42, 31 female) and without (n = 58, 33 female). It investigated the interrelation of the effects of social anxiety disorder and early-life adversity (a main environmental risk factor of social anxiety disorder) on brain activity during an attentional control task. We applied DNA methylation analysis to determine whethe

SUBMITTER: Wiegand A 

PROVIDER: S-EPMC8687622 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature