The enteric pathogen Cryptosporidium parvum exports proteins into the cytosol of the infected host cell.

ABSTRACT: The parasite Cryptosporidium is responsible for diarrheal disease in young children causing death, malnutrition, and growth delay. Cryptosporidium invades enterocytes where it develops in a unique intracellular niche. Infected cells exhibit profound changes in morphology, physiology, and transcriptional activity. How the parasite effects these changes is poorly understood. We explored the localization of highly polymorphic proteins and found members of the Cryptosporidium parvum MEDLE protein family to be translocated into the cytosol of infected cells. All intracellular life stages engage in this export, which occurs after completion of invasion. Mutational studies defined an N-terminal host-targeting motif and demonstrated proteolytic processing at a specific leucine

SUBMITTER: Dumaine JE 

PROVIDER: S-EPMC8687662 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature