Ontology highlight
ABSTRACT:
SUBMITTER: Izumi H
PROVIDER: S-EPMC8687755 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Izumi Hiroki H Matsumoto Shingo S Liu Jie J Tanaka Kosuke K Mori Shunta S Hayashi Kumiko K Kumagai Shogo S Shibata Yuji Y Hayashida Takuma T Watanabe Kana K Fukuhara Tatsuro T Ikeda Takaya T Yoh Kiyotaka K Kato Terufumi T Nishino Kazumi K Nakamura Atsushi A Nakachi Ichiro I Kuyama Shoichi S Furuya Naoki N Sakakibara-Konishi Jun J Okamoto Isamu I Taima Kageaki K Ebi Noriyuki N Daga Haruko H Yamasaki Akira A Kodani Masahiro M Udagawa Hibiki H Kirita Keisuke K Zenke Yoshitaka Y Nosaki Kaname K Sugiyama Eri E Sakai Tetsuya T Nakai Tokiko T Ishii Genichiro G Niho Seiji S Ohtsu Atsushi A Kobayashi Susumu S SS Goto Koichi K
Nature 20211124 7888
Lung cancer is one of the most aggressive tumour types. Targeted therapies stratified by oncogenic drivers have substantially improved therapeutic outcomes in patients with non-small-cell lung cancer (NSCLC)<sup>1</sup>. However, such oncogenic drivers are not found in 25-40% of cases of lung adenocarcinoma, the most common histological subtype of NSCLC<sup>2</sup>. Here we identify a novel fusion transcript of CLIP1 and LTK using whole-transcriptome sequencing in a multi-institutional genome sc ...[more]