Single-cell transcriptomic landscapes of a rare human laryngeal chondrosarcoma.

ABSTRACT:

Propose

Laryngeal chondrosarcoma is a rare non-epithelial malignant tumor. At present, the cell type composition and molecular mechanism of laryngeal chondrosarcoma have not been systematically studied.

Methods

This study focused on the histopathological and imaging features of a rare primary laryngeal chondrosarcoma in a 74-year-old male. The tumor and its paracancerous cartilage tissue were single-cell sequenced and analyzed and a total of 5455 single cells were obtained. Immunohistochemical levels were also verified.

Results

In total five cell types were identified, including chondrocytes, myeloid cells, fibroblasts, lymphocytes, and endothelial cells. We carried out further subgroup analysis, focusing on the classification and differentiation of chondrocytes, func

SUBMITTER: Lin C 

PROVIDER: S-EPMC8688141 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature