NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding.

ABSTRACT: In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD⁺, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. Although NAD⁺ also participates in redox reactions, the extent to which NAD(H) couples nutrient state with circadian transcriptional cycles remains unknown. Here we show that nocturnal animals subjected to time-restricted feeding of a calorie-restricted diet (TRF-CR) only during night-time display reduced body temperature and elevated hepatic NADH during daytime. Genetic uncoupling of nutrient state from NADH redox state through transduction of the water-forming NADH oxidase from Lactobacillus brevis (LbNOX) increases daytime body temperature

SUBMITTER: Levine DC 

PROVIDER: S-EPMC8688143 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature