Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease.

ABSTRACT:

Background

Neurofilament light chain protein (NfL) is a promising biomarker of neurodegeneration.

Objectives

To determine whether plasma and CSF NfL (1) associate with motor or cognitive status in Parkinson's disease (PD) and (2) predict future motor or cognitive decline in PD.

Methods

Six hundred and fifteen participants with neurodegenerative diseases, including 152 PD and 200 healthy control participants, provided a plasma and/or cerebrospinal fluid (CSF) NfL sample. Diagnostic groups were compared using the Kruskal-Wallis rank test. Within PD, cross-sectional associations between NfL and Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) and Mattis Dementia Rating Scale (DRS-2) scores were assessed by linear regression; longitudinal analyses were perfor

SUBMITTER: Aamodt WW 

PROVIDER: S-EPMC8688198 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature