Disparities in older adult accrual to cancer trials: Analysis from the alliance for clinical trials in oncology (A151736).

ABSTRACT:

Background

Older adults are under-represented in cancer clinical trials. However, it remains unclear which types of trials under-enroll aging patients. We aimed to identify associations between trial characteristics and disparate enrollment of older adults onto trials sponsored by the Alliance for Clinical Trials in Oncology (Alliance).

Methods

Actual age ≥ 65 percentage and trial data were extracted from the Alliance closed study list. Each trial, based on its cancer type and years of enrollment, was assigned an expected age ≥ 65 percentage extracted from the Surveillance, Epidemiology, and End Results (SEER) US population-based database. Enrollment disparity difference (EDD), the difference between the expected age ≥ 65 percentage and the actual age ≥ 65 percentage, was ca

SUBMITTER: VanderWalde NA 

PROVIDER: S-EPMC8688206 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature