NMDA receptor-mediated synaptic transmission in prefrontal neurons underlies social memory retrieval in female mice.

ABSTRACT: Social memory is the ability to discriminate familiar conspecific from the unknown ones. Prefrontal neurons are essentially required for social memory, but the mechanism associated with this regulation remains unknown. It is also unclear to what extent the neuronal representations of social memory formation and retrieval events overlap in the prefrontal cortex (PFC) and which event drives social memory strength. Here we asked these questions by using a repeated social training paradigm for social recognition in FosTRAP mice. We found that after 4 days' repeated social training, female mice developed stable social memory. Specifically, repeated social training activated more cells that were labeled with tdTomato during memory retrieval compared with the first day of memory encoding. Besides

SUBMITTER: Zhang YX 

PROVIDER: S-EPMC8688302 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature