The penalty of stress - Epichaperomes negatively reshaping the brain in neurodegenerative disorders.

ABSTRACT: Adaptation to acute and chronic stress and/or persistent stressors is a subject of wide interest in central nervous system disorders. In this context, stress is an effector of change in organismal homeostasis and the response is generated when the brain perceives a potential threat. Herein, we discuss a nuanced and granular view whereby a wide variety of genotoxic and environmental stressors, including aging, genetic risk factors, environmental exposures, and age- and lifestyle-related changes, act as direct insults to cellular, as opposed to organismal, homeostasis. These two concepts of how stressors impact the central nervous system are not mutually exclusive. We discuss how maladaptive stressor-induced changes in protein connectivity through epichaperomes, disease-associated pathologic

SUBMITTER: Ginsberg SD 

PROVIDER: S-EPMC8688321 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature