Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response.

ABSTRACT: Fast fMRI enables the detection of neural dynamics over timescales of hundreds of milliseconds, suggesting it may provide a new avenue for studying subsecond neural processes in the human brain. The magnitudes of these fast fMRI dynamics are far greater than predicted by canonical models of the hemodynamic response. Several studies have established nonlinear properties of the hemodynamic response that have significant implications for fast fMRI. We first review nonlinear properties of the hemodynamic response function that may underlie fast fMRI signals. We then illustrate the breakdown of canonical hemodynamic response models in the context of fast neural dynamics. We will then argue that the canonical hemodynamic response function is not likely to reflect the BOLD response to neuronal ac

SUBMITTER: Polimeni JR 

PROVIDER: S-EPMC8688322 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature