Interaction effect of serum serotonin level and age on the 12-week pharmacotherapeutic response in patients with depressive disorders.

ABSTRACT: Despite the recognized antidepressant role of serotonin (5-hydroxytryptamine [5-HT]) signaling pathways in the central nervous system, the association between baseline peripheral 5-HT level and the antidepressant treatment response in clinical studies remains debatable. We investigated the interaction effects of baseline serum 5-HT level and age on the 12-week remission in outpatients with depressive disorders who received stepwise antidepressant treatment. Baseline serum serotonin levels were measured and the age of 1094 patients recorded. The patients received initial antidepressant monotherapy; then, patients with an insufficient response or who experienced uncomfortable side effects received alternative treatments every 3 weeks (3, 6, and 9 weeks). Subsequently, 12-week remission, defi

SUBMITTER: Choi W 

PROVIDER: S-EPMC8688427 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature