Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter.

ABSTRACT: Intersubject variability is a fundamental characteristic of brain organizations, and not just "noise". Although intrinsic functional connectivity (FC) is unique to each individual and varies across brain gray-matter, the underlying mechanisms of intersubject functional variability in white-matter (WM) remain unknown. This study identified WMFC variabilities and determined the genetic basis and macroscale imaging in 45 healthy subjects. The functional localization pattern of intersubject variability across WM is heterogeneous, with most variability observed in the heteromodal cortex. The variabilities of heteromodal regions in expression profiles of genes are related to neuronal cells, involved in synapse-related and glutamic pathways, and associated with psychiatric disorders. In contrast,

SUBMITTER: Li J 

PROVIDER: S-EPMC8688465 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature