Ontology highlight
ABSTRACT:
SUBMITTER: Cleghorn WM
PROVIDER: S-EPMC8688572 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Cleghorn Whitney M WM Burrell Anika L AL Giarmarco Michelle M MM Brock Daniel C DC Wang Yekai Y Chambers Zachary S ZS Du Jianhai J Kollman Justin M JM Brockerhoff Susan E SE
The Journal of biological chemistry 20211120 1
Inosine monophosphate dehydrogenase (IMPDH) is a key regulatory enzyme in the de novo synthesis of the purine base guanine. Dominant mutations in human IMPDH1 cause photoreceptor degeneration for reasons that are unknown. Here, we sought to provide some foundational information on Impdh1a in the zebrafish retina. We found that in zebrafish, gene subfunctionalization due to ancestral duplication resulted in a predominant retinal variant expressed exclusively in rod and cone photoreceptors. This v ...[more]