Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer.

ABSTRACT:

Background

There is a critical need to better understand the mechanisms that drive local cell invasion and metastasis to develop new therapeutics targeting metastatic disease. Bioelectricity is an important mediator of cellular processes and changes in the resting membrane potential (RMP) are associated with increased cancer cell invasion. However, whether the RMP can be used to target invading cancer cells is unknown.

Methods

We employed both genetic and pharmacological manipulation of potassium channel activity and characterized the effects on breast cancer cell migration and invasion in vitro, and metastasis in an animal model of breast cancer.

Findings

Our data demonstrate that altering the RMP of triple-negative breast cancer (TNBC) cells by manipulating potassiu

SUBMITTER: Payne SL 

PROVIDER: S-EPMC8688589 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature