Composition and Diversity of the Ocular Surface Microbiota in Patients With Blepharitis in Northwestern China.

ABSTRACT: Purpose: To investigate the composition and diversity of the microbiota on the ocular surface of patients with blepharitis in northwestern China via 16S rDNA amplicon sequencing. Methods: Thirty-seven patients with blepharitis divided into groups of anterior, posterior and mixed blepharitis and twenty healthy controls from northwestern China were enrolled in the study. Samples were collected from the eyelid margin and conjunctival sac of each participant. The V3-V4 region of bacterial 16S rDNA in each sample was amplified and sequenced on the Illumina HiSeq 2500 sequencing platform, and the differences in taxonomy and diversity among different groups were compared. Results: The composition of the ocular surface microbiota of patients with blepharitis was similar to tha

SUBMITTER: Wang C 

PROVIDER: S-EPMC8688757 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature