Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia.

ABSTRACT: The behavioural variant of frontotemporal dementia is a clinical syndrome characterized by changes in behaviour, cognition and functional ability. Although atrophy in frontal and temporal regions would appear to be a defining feature, neuroimaging studies have identified volumetric differences distributed across large parts of the cortex, giving rise to a classification into distinct neuroanatomical subtypes. Here, we extended these neuroimaging studies to examine how distributed patterns of cortical atrophy map onto brain network hubs. We used baseline structural magnetic resonance imaging data collected from 213 behavioural variant of frontotemporal dementia patients meeting consensus diagnostic criteria and having definite evidence of frontal and/or temporal lobe atrophy from a global c

SUBMITTER: Vuksanovic V 

PROVIDER: S-EPMC8688778 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature