The Clinical Course of Alcohol Use Disorder Depicted by Digital Biomarkers.

ABSTRACT: Aims: This study introduces new digital biomarkers to be used as precise, objective tools to measure and describe the clinical course of patients with alcohol use disorder (AUD). Methods: An algorithm is outlined for the calculation of a new digital biomarker, the recovery and exacerbation index (REI), which describes the current trend in a patient's clinical course of AUD. A threshold applied to the REI identifies the starting point and the length of an exacerbation event (EE). The disease patterns and periodicity are described by the number, length, and distance between EEs. The algorithms were tested on data from patients from previous clinical trials (n = 51) and clinical practice (n = 1,717). Results: Our study indicates that the digital biomarker-ba

SUBMITTER: Zetterstrom A 

PROVIDER: S-EPMC8688853 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature